[10][11][2] Afriyie Akoto first contested the Kwadaso constituency seat in 2004 and received 20 of the total votes cast by delegates.

While at Parliament, Afriyie Akoto was the Deputy Ranking Member for the Committee on Food and Agriculture and Cocoa Affairs.

[15] In January 2017, President Nana Akufo-Addo nominated Afriyie Akoto for the position of Minister of Food and Agriculture.

[28] As the Minister of Food and Agriculture, Afriyie Akoto promised to increase the percentage of farmers who use improved seeds for farming, which as of June 2017 stood at eleven percent.

[29] He has also made it known that the government will be collaborating with the Savanna Agricultural Research Institute and the Grains Development Board to overcome the deficit in the supply of seeds for the Planting for Food and Jobs programme.

[30] He is credited for designing and implementing the Government of Ghana's flagship Planting for Food and Jobs programme, which was launched on 19 April 2017.

[37][38][39][40] On the other hand, Afriyie Akoto fired at critics for failing to see the intended impact of the Planting for Food and Jobs programme.

[43] As a cabinet minister, Afriyie Akoto is part of the president's inner circle and is to aid in key decision-making activities in the country.

[43] Following his resignation from his role as Minister of Food and Agriculture, Afriyie Akoto has disclosed his ambition to run for President of the Republic of Ghana under the ticket of the New Patriotic Party (NPP) in the 2024 General Elections.

[47][48] After filing his nomination forms, he indicated that the NPP party cannot 'Break the 8' with a divided front and hence the need to constitutional allow delegates to make the decision.

[50] This balloting took place in anticipation of the special delegates conference, which is scheduled to be held on the 26th of August, 2023[51][52] Afriyie Akoto is married with seven children.