Oxilofrine, sold under the brand names Carnigen and Suprifen among others, is a sympathomimetic medication which has been used as an antihypotensive agent and cough suppressant.

[4][7][6] It acts as a norepinephrine releasing agent and indirectly activates the α- and β-adrenergic receptors.

Trade names included Suprifen (Bayer) and, combined with an adenosine-containing standardized organ extract, Carnigen (Hoechst AG).

[9] In combination with normethadone, it was marketed as a cough suppressant under the trade name Ticarda.

[17] Several other sympathomimetics and vasodilators were developed as chemical derivatives of oxilofrine, such as the β2-adrenergic receptor agonists buphenine and isoxsuprine.

[9][21] Even after receiving warning letters from the FDA,[22] some sports and weight loss supplement companies continue to use oxilofrine as an undeclared ingredient in their products despite it being prohibited.