The PFL 10 mixed martial arts event for the 2019 season of the Professional Fighters League, the 2019 PFL Championship, was held on December 31, 2019, at the Hulu Theater at Madison Square Garden in New York City, New York.

Kelvin Tiller was eventually chosen to return to the competition to face Jared Rosholt.

[2] *Magomed Magomedkerimov was originally scheduled to face Ray Cooper III but was unable to continue in the tournament.

[3] [4] *Daniel Pineda was originally scheduled to face Lance Palmer but was forced to pull out of the bout after failing NAC drug test.

[6] * Genah Fabian was originally scheduled to face Kayla Harrison but was forced to pull out of the bout.