: 84 [7] The PINSTECH is located in Nilore, about 15 mi (24 km) southeast of Islamabad, and was designed by the American firm, AMF Atomics and Edward Durell Stone who once worded: "This....has been my greatest work.

[7] The scientific research programs are supported at the laboratory through the Pakistan Institute of Engineering and Applied Sciences, also in Nilore.

[3] From 1965–69, the Pinstech had an active and direct laboratory-to-laboratory interaction with the American national laboratories such as Oak Ridge, Argonne, Livermore, and Sandia.

: 269 [9][10][11] The scientific library of the institute consisted of a large section containing historical references and literatures on the Manhattan Project, brought by Abdus Salam in 1971 prior to start of the nuclear weapons program under Zulfikar Ali Bhutto's administration.

[3] In spite of its short-comings, the investigations and classified studies on understanding the equation of state on plutonium was started the physicists at the Pinstech laboratory in 1972.

[3] At the Pinstech laboratory, a pilot plant (New Labs) was built for reprocessing spent reactor fuel into plutonium pit production.

: 115 [7] In 1973, the lab conducted several studies on understanding the properties of uranium oxide, eventually producing the first fuel bundle in 1976 that was shipped to the Karachi Nuclear Power Plant to keep its grid operations running.

: 106 [7] The Pinstech also took initiatives in learning and understanding the chemistry of uranium hexafluoride, which the technology was transferred to the Islamabad Uranium Conversion Facility in 1974.: 115–116  In addition, the understanding of UF6 eventually led in producing the Zircaloys, which it was also produced at the lab first; and later having it transfer the technology to the Kundian Nuclear Fuel Complex in 1980.: 115–116 As of today, PINSTECH has been shifted to peacetime research in medicine, biology, materials and physics.

Since its repurposing in 1972, the Pinstech laboratory conducts research into understanding the equation of state of plutonium, its phase diagrams, and its properties.

: 176 [7] Research work on plutonium is conducted at its special-purpose facility, the New Laboratories, where the weapon-grade nuclear explosives are designed and manufactured.