3V4Y5511100336ENSG00000117751ENSMUSG00000028882Q12972Q8R3G1NM_138558NM_002713NM_014110NM_001290725NM_146154NM_001355198NM_001355199NP_002704NP_054829NP_612568NP_001277654NP_666266NP_001342127NP_001342128Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.

[5][6][7] This gene, through alternative splicing, encodes three different isoforms.

The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli.

This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

[7] PPP1R8 has been shown to interact with PPP1CA,[8][9] Histone deacetylase 2,[8] SF3B1[10] EED[8] and the EZH2 domain of PRC2.