1027954373ENSG00000112812ENSMUSG00000006179Q9NQE7Q9QXE5NM_005865NM_019429NP_005856NP_062302Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.

[5][6] This gene encodes a serine protease expressed exclusively in the thymus.

It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells.

The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region.

A second transcript variant has been described, but its full length nature has not been determined.