Pa Tio (Thai: ป่าติ้ว, pronounced [pàː tîw]; Northeastern Thai: ป่าติ้ว, pronounced [páː tîw]) is a district of Yasothon province in northeastern Thailand.

Around 1889, there was an influx of Lao settlers into the Isan region after a large area of Thailand east of the Mekong River was ceded to the French.

The road passed through Pa Tio village, and led to its growth and expansion.

In 1951, a petition was made for Pa Tio to be given minor district (king amphoe) status with jurisdiction over three (tambons): Pho Sai, Krachai, and Khok Na Ko, but it was not until 17 August 1966 that it was officially made so.

[1] In 1969, Pa Tio was raised to district (amphoe) status, in Ubon Ratchathani Province.