Affiliated with the Canadian Association of Blue Cross Plans, Pacific Blue Cross dates back to the 1940s, when its predecessor organizations – the Medical Services Association (MSA) and CU&C (Credit Union & Cooperative) Health Services Society – were founded.

Both companies grew steadily and successfully dealt with major challenges, including the introduction of Medicare and the merger that brought the two former competitors together as Pacific Blue Cross in 1997.

In 2015, Pacific Blue Cross was named the 15th Most Loved Brand in British Columbia by BC Business.

[4] Following the departure of Jan K. Grude, John Crawford was appointed President and CEO in August 2018.

Notable initiatives of Pacific Blue Cross include Text-Blue-Wish[6] in support of the Children's Wish Foundation of Canada and Share the Care which celebrated their 75th anniversary by donating $75,000.