The shoreline of Mangilao, notably the Marine Lab of the University of Guam lies along the northeast bay, outside of the fringing reef.

[1] The Frank Perez Park, a public recreation area, is located northeast of the river mouth.

There are many archeological finds along both sides of the mouth of the river from the Latte Period (900-1521), including an earth-oven, human burials, pottery fragments, shells ornaments, and many other artifacts.

[2] During the Spanish-Chamorro Wars of the late seventeenth century, the Spanish colonizers relocated CHamorus into centralized towns, a process of villagization to better control the population known as the Reducción.

[3]: 62  In 1689, the enshrinement of Santa Marian Kamalen at the church in Pago was attended by Ignacio Hineti, Antonio Ayhi and other prominent pro-Spanish CHamoru Christians.

[5] Pago Bay is integral to a CHamoru folktale explaining why Guam has a narrow central "waist."

The maidens gathered at Hagåtña Springs and cut off their long black hair to make a magical net and started to sing.

[10] However, the developers have run afoul of regulators regarding reburial of ancient human remains[11] and missing deadlines to give updates to the Guam Land Use Commission.

[12] The University of Guam began a water quality data collection and management plan for the Pago Bay watershed in 2015.

Called "Builders of a Better Bay," it uses student researchers to collect data on turbidity and water level, as well as interview historical experts about the cultural significance of the area.