Painkiller Jane is a fictional superheroine created by Jimmy Palmiotti and Joe Quesada for Event Comics in 1995.

Originally a five-issue mini-series, the character went on to star in numerous crossover titles with the likes of the Punisher, Vampirella, and Hellboy.

After gaining the trust of mob boss Joey Fonti, she is given the assignment of passing a message on to rival gang member Adam, not realizing that an explosive device has been planted on her.

Jane Vasko is virtually indestructible; her exceptional regenerative abilities mean that minor injuries heal in seconds and do not even slow her down while more major ones tend to take a few minutes.

She has recovered from multiple gunshot wounds, explosions, chemical weapons, axes buried in her spine, even a shotgun blast to the face (which simply knocked her off her feet for a bit).