The Palazzo Angelo Giovanni Spinola is a palace located in Via Garibaldi, in the historical center of Genoa, in Northwestern Italy.

On 13 luglio del 2006 it was included in the list of 42 palaces which now form the UNESCO World Heritage Site Genoa: Le Strade Nuove and the system of the Palazzi dei Rolli.

The Rolli di Genova - or, more precisely, the Rolli degli alloggiamenti pubblici di Genova (Italian for "Lists of the public lodgings of Genoa") were the official lists at the time of the Republic of Genoa of the private palaces and mansions, belonging to the most distinguished Genoese families, which - if chosen through a public lottery - were obliged to host on behalf of the Government the most notable visitors during their State visit to the Republic.

In 1919, the palace was sold to the bank Crédit Commercial de France and was converted into an office building.

The facade of the palace is decorated with frescoes executed by the Calvi brothers, possibly together with Lazzaro Tavarone.