The Palazzo Cesarò Colonna, sometimes called Palazzo Cesarò, is a former aristocratic palace located on via Cassaro #417, now called Via Vittorio Emanuele, facing the church of Santissimo Salvatore in the quarter of Seralcadio, in the historic center of Palermo, region of Sicily, Italy.

The site once was known as the Palazzo Cesarò, and built under the patronage of the Tetano and Giusino family, by the mid-eighteenth century.

The palace became both a boarding house, and was celebrated for salons, but also as a gambling parlor for the aristocracy.

In the 19th century, the Palazzo Cesarò was bought by doctor Stefano Tedeschi Oddo, a physician who earned a medal from Garibaldi for his service at the Battle of Calatafimi.

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