The Contrari family was one of the richest and most important in Ferrara from the 12th century, very close and related to the Estensi.

[1] One of the first members of the family to hold public office was Pietro Contrari, Consul of Ferrara from 1127 to 1135 and the most prominent personality was the 3rd Count of Vignola Uguccione II, deceased in 1516 (consort of Diana d'Este, daughter of Sigismondo I d'Este), who among his other duties and titles was lieutenant of the Duchy of Ferrara and captain general of the duke's armies.

In addition to Uguccione, Count Ercole Contrari, captain of the ducal guard who had a long relationship with Lucrezia d'Este, also lived in the palace from 1413.

[3][4] The building, dating from before the 14th century, was initially equipped with battlements that collapsed during the Ferrara earthquake of 1570.

It was later modified, but retains a monumental appearance, thanks in part to the beautiful rusticated marble portal that recalls other noble residences such as the Delizia del Verginese or the Ducal Baths.