Palazzo Re Enzo is a palace located on Piazza del Nettuno, 1 in the historic center of Bologna, northern Italy.

[1] The palace was built between 1244 and 1246 as an extension of the nearby Palazzo del Podestà, which had proven insufficient for the exigences of the Commune of Bologna.

Three years after the palace completion, Enzio was captured by the Guelphs at the Battle of Fossalta, and after a short stay in Anzola he was moved here, where he remained until his death.

He was also allowed to meet women: in his will he mentions three natural daughters, but a legend talks about a fourth son he had from a peasant, Lucia di Viadagola.

In 1386 Antonio di Vincenzo finished the Sala dei Trecento ("Hall of the Three-Hundred"), which was to become the city's archive.