Palazzo Crispo Marsciano, previously known simply as the Palazzo Marsciano is a Renaissance architecture palace located on Via Postierla #9 on Piazza Marconi in the historic center of Orvieto in the region of Umbria, Italy.
The palace was commissioned by Tiberio Crispo, who had three maternal half-brothers that were sons of Cardinal (al secolo) Alessandro Farnese, who became Pope Paul III, and his mistress.
In the 1540s, Crispo was appointed governor of Perugia, castellan of Castel Sant’Angelo, and finally cardinal in 1544.
This palace was designed circa 1540 by Antonio da Sangallo the younger.
The nuns of the adjacent convent of San Bernardino purchased the palace in 1618.