By 1514, the palace was documented to belong to a Marco Donà, and two carved stones at the entrance sported the family shield.
There is another Palazzo Donà della Madoneta on the Grand Canal shore of the Sestiere of San Polo.
The palace at San Severo remained in this family till 1582 when it appears to have been sold to two brothers Troilo and Sertorio Altan, who were cloth merchants in Venice and the mainland.
The Altàn had built tombs in the church of Sant'Anna and had lent to Donà a sum of money, to obtain the palace at San Severo.
[2] In a room of this palace, later converted to oratory, there is an epigraph in black stone recalling the birth here of the future pope.