It's located in an area rich in archaeological remains of ancient Rome, which has been the result of numerous modifications and restoration works carried out by several noble Roman families who lived there over the centuries.

The oldest sources connects the palace to the Ercolani family and was initially built by Giacomo della Porta.

The family of Luigi Gottifredi, a priest of the Society of Jesus, who settled there, made a radical renovation employing Camillo Arcucci, an architect of the Roman Baroque, in the years 1645 to 1650.

In the early 19th century, the palace was the residence of the Ambassador of Austria and then the Infanta of Spain and Duchess of Lucca, Maria Luisa of Bourbon-Spain who died there in 1824.

It was later acquired by Commander Grazioli, then Baron of Castelporziano and Duke of Santa Croce di Magliano, who in 1863 entrusted the restoration which ended in 1874.