Among the prominent figures of the family was Giannozzo Manetti, a humanist and translator of Aristotle, who was disliked by Cosimo the Elder.

Therefore, with the return of the pater patriae to Florence, he was forced to leave the city, first moving to Naples and then to Rome, where he initiated the collection of the Vatican Library.

[3] From 1737 onwards, there is an extensive correspondence with Horace Walpole, son of the Minister Sir Robert Walpole, in which he meticulously describes everything that happens in Florence, from the death of Gian Gastone de' Medici to that of the Electress Palatine (falling "ruining" the carnival), up to the arrival of the Lorraines.

[4][5] A painting by Thomas Patch entitled Gentlemen in the House of Horace Mann, once owned by the antiquarian Enrico Hughford, remains of that Florentine salon.

The present appearance heavily reflects nineteenth-century interventions, which have altered both the facade and the interiors, especially in the part facing the garden.