Palazzo Palmerini (formerly Mastrandrea) is a 16th century civic building located in Alcamo, in the province of Trapani: the Palace is situated at Via Buonarroti.

The ownership of this mansion to the Mastrandrea family is deduced from the deed drawn by the notary Aversa on 16 June 1562.

The historian Pietro Maria Rocca, from Alcamo, mentions some notarial contracts, between 1533 and 1534, which testify that the tower was built in this period.

On the first floor are a window and two balconies with stone corbels, and a recent one with a marble gallery which is sustained by iron supports.

[3] Between 1835 and 1841 the building was divided into different parts by the owner, signora Orofino Palmerini, and leased to four families simultaneously.