The Palazzo San Giuliano is a monumental palace located in Piazza Universitaria, in the center of the city of Catania, Sicily, southern Italy.
Once a private home of the San Giuliano branch of the House of Paternò, it has also served as hospital, bank, theater, and hotel.
After the 1693 Sicily earthquake raze the prior structure at the site, a palace was commissioned by the Marquise of San Giuliano, a member of the aristocratic Paternò family.
The portal has two coat of arms, one on the left from the Paternò Castello family, and on the right from the Asmundos, later aristocratic owners of the palace.
Inside the courtyard is a typical double flight of stairs to the piano nobile.