Historically belonging to the sestiere di Porta Nuova, it is located at 10 Via San Paolo.

Hypotheses have been put forward regarding Pellegrino Pellegrini and Martino Bassi, but only Bassi's participation would now seem undoubted; today, the building owes much of its interior appearance to 19th-century alterations:[3] the simple façade, in which the ashlar-work portal stands out, allows little to be seen of the luxurious interiors.

Famous is the Sala d'oro designed by Gerolamo Arganini and decorated by Giacomo Tazzini: the hall, remodelled on the occasion of the wedding of Emperor Ferdinand I, is spacious and monumental, surrounded by a colonnade decorated with fregi and surmounted by the entablature forming the tribune for the orchestra;[1] the frescos and gilded stuccoes on an ivory background also stand out; similarly the Sala d'silver named after the silver-coloured stuccoes by Luigi Tatti.

Badly hit by Anglo-American bombing in 1943, the building caught fire and although the architecture of the façade and courtyard remained intact, the fire destroyed almost all of the upper floors and parts of the ground floor, resulting in the collapse of the roofs and most of the vaults and the loss of the two rooms described above, of which only the walls were saved.

[4] Palazzo Spinola housed until his death the large studio of the painter Luigi Conconi (1852—1917), who shared it for a long time with Gaetano Previati (1852—1920).