The Palazzo degli Alessandri is an early-Renaissance-style palace located on Borgo degli Albizi number 15 in Florence, Region of Tuscany, Italy.

The two brother Alessandro and Bartolomeo degli Albizi (after 1372 called 'degli Alessandri') built the palace after the purchasing of three lots between 1368-72 and probably completed by 1376.

During the Ciompi rebellion of 1378 the palace was ransacked and arson, the west side of the structure collapsed (the lack of rustication is still visible today).

The coat of arms of the Alessandri was a two heads lamb on a blue field with a gold crown and palm leaves.

Antonio Canova was patronized by the Alessandri family.