The Palazzo dei Priori is a 13th-century civic palace located in Piazza del Plebiscito in central Viterbo, region of Lazio, Italy.
Across the piazza on the north end of the Palazzo dei Priori is the church of Sant'Angelo in Spatha, which has a marble replica of the Ancient Roman Sarcophagus of Bella Galiana on the facade.
The facade of the Palazzo dei Priori was completed during the reign of Pope Sixtus IV della Rovere (1471–1484) by Bernardo Rossellino.
The chapel of the commune (also called Capella Palatina) was decorated by Filippo Caparozzi and Marzio Ganassino in the early 17th century.
The library retains portraits of the historian Francesco Orioli and the scholar Antonio Tagliaferri, who instituted in 1502 the academic society known as the Accademia degli Ardenti.