During its final year it was operated by the Seaboard Coast Line Railroad (the post-merger successor of the Atlantic Coast Line Railroad).

In addition to its main terminal points in Augusta and Savannah, the Palmetto had a branch that went to Wilmington, North Carolina's Union Station.

At Augusta Union Station the train had a connection to Georgia Railroad's train from Augusta to Atlanta's Union Station.

By 1963 the ACL trimmed its south of Richmond meal services to a cafe-lounge between Florence and Augusta, leaving the Savannah and Wilmington branches without food catering.

[3] By 1965, the Savannah branch was dropped and Wilmington-bound riders had to change to another train at Rocky Mount.