Palmieri is a lunar impact crater that lies to the southwest of the Mare Humorum, in the southwestern quadrant of the Moon's near side.

The remains of a small, flooded crater form the northern edge of the gap along the southeast.

This floor is joined with a long expanse of lava surface to the north of Palmieri that proceeds northwards until it reaches the area between Liebig and de Gasparis.

The floor is marked by a system of rilles named the Rimae Palmieri that continue to the north and southeast beyond the crater perimeter.

By convention these features are identified on lunar maps by placing the letter on the side of the crater midpoint that is closest to Palmieri.