Palmitate mediated localization is a biological process that trafficks a palmitoylated protein to ordered lipid domains.
[1] One function is thought to cluster proteins to increase the efficiency of protein-protein interactions and facilitate biological processes.
In the opposite scenario palmitate mediated localization sequesters proteins away from a non-localized molecule.
In theory, disruption of palmitate mediated localization then allows a transient interaction of two molecules through lipid mixing.
Depletion of cholesterol with methyl-beta cyclodextrin disrupts palmitate mediated localization.