Pamela Sklar (born July 20, 1959, in Baltimore, Maryland - died November 20, 2017, in New York City) was an American psychiatrist and neuroscientist.

Sklar's research and clinical work focused on characterizing the biology underlying mental illnesses, in particular schizophrenia and bipolar disorder.

[4][5] While working at the Broad Institute, Sklar co-founded the Stanley Center for Psychiatric Research and served as its genetics director.

By studying thousands of affected individuals and comparing them with thousands of healthy people, she was the first to associate recurrent large deletions of DNA with the onset of schizophrenia and also found the first broadly reproducible genetic variants in schizophrenia as well as bipolar disorder using genome-wide association studies.

[12][13] In 2011, Sklar joined the Icahn School of Medicine at Mount Sinai and became founding chief of the Division of Psychiatric Genomics there.