Pamplona is the result of the fusion of two villages during the Spanish era; Abulacan (now barrio San Juan) and Masi.

This is the reason why the town fiesta is celebrated for two days and the images of the two patron saints are carried during religious processions.

The transfer was made on November 16, 1919, during the administration of municipal president Esteban Meneses by order of General Wood.

Because of the river's strong current and unpredictable floods, Mayor Nicolas B. Aquino built in 1955 a concrete levee along Barangay Masi.

[5] On August 5, 2016, Vice Mayor Aaron Sampaga was assassinated in his friend's compound in Barangay Masi by motorcycle-riding gunmen.

Poverty Incidence of Pamplona Source: Philippine Statistics Authority[14][15][16][17][18][19][20][21] Pamplona, belonging to the second legislative district of the province of Cagayan, is governed by a mayor designated as its local chief executive and by a municipal council as its legislative body in accordance with the Local Government Code.