The Pan-Mass Challenge (PMC) is a fundraising bike-a-thon started in 1980 by Billy Starr to benefit the Dana–Farber Cancer Institute via the Jimmy Fund.

[11] Notable past riders in the PMC include former NFL quarterback Alex Smith,[12] three-time Tour de France winner Greg LeMond,[13] Olympic speed skater Johann Olav Koss, multiple Boston Marathon winner Uta Pippig,[14] three-time Super Bowl champion Troy Brown,[15] Joshua Bekenstein (a PMC board member), Dana-Farber CEO Laurie Glimcher,[16] Massachusetts Governor Charlie Baker, Boston mayor Marty Walsh,[17] restaurateur Jody Adams,[18] former Secretary of State John Kerry,[19] Nobel laureate William Kaelin,[20] Senator Scott Brown,[21] Judge Samuel Zoll,[22] Overstock.com CEO Patrick Byrne,[23] and football player Joe Andruzzi.

[24] Each August, cyclists ride for one or two days,[25] on one of 16 routes ranging from 25 to 211 miles long[26] running through 47 Massachusetts towns.

[42] The PMC generates 62% of the Jimmy Fund's annual revenue as of 2023[update][43] and is the Dana–Farber Cancer Institute's single largest donor.

[47] Since 2007, 100 percent of the money raised by riders goes to the Dana–Farber Cancer Institute, with all event overhead funded by sponsors, entry fees, and other income.