He was influenced by early members of the movement namely: Elias Moskos, Theodoros Poulakis, Stephanos Tzangarolas, Spyridon Sperantzas and Victor.

Doxaras painted notable portraits of Johann Matthias von der Schulenburg.

[1][2][3] Panayiotis was born in a small village named Koutifari close to Kalamata in the Peloponnese region.

His parents signed an agreement with famous painter Leos Moskos to teach him painting.

He also translated the works of Leon-Battista Alberti, Andrea Pozzo, and a massive catalog with the most famous painters in the world.

His book Common Teaching (Keni Didaskalia) was inspired by Marco Boschini's, Le Ricche Minere della Pittura Veneziana.

[6] In 1721, the Venetian government gave Panayiotis land in Lefkada, but in 1722 he preferred to move to Corfu.

[7][8][9] Panayioti's work signals a departure from Greek painting, namely the Cretan school and maniera greca towards Western European Renaissance art.

Panayiotis admired the Italian masters particularly Leonardo da Vinci, whose book Art of painting (Trattato della pittura) he translated into Greek.

[10] In 1726, he wrote the famous, albeit controversial and debated theoretical text On painting (Περί ζωγραφίας).

The images faded and in the middle of the 19th century and were replaced with newer ones painted by Nikolaos Aspiotis.