Just a week after its separation from Colombia, on November 10, 1903, the newly established Republic of Panama sent a letter (through its Minister of Foreign Affairs Francisco Vicente de la Espriella) to the government of the Oriental Republic of Uruguay, requesting diplomatic recognition.

[2] On October 15, 1912 Uruguay appointed Guillermo Irarrazaval Smith as its consul in Panama.

[4] In late 1918 Baltasar Brum, Minister of Foreign Affairs and president-elect of Uruguay, visited Panama.

The Panamanian envoy in Buenos Aires, Juan Ehrman Lefevre, was appointed as the representative of Panama towards Uruguay.

[6] In January 1927 the Uruguayan government decided to established a general consulate based in Mexico City, which jurisdiction included Panama.