During the Spanish Regime, Pandi was a part of the political jurisdiction of the town of Meycauayan City including the towns of San Jose del Monte, Bocaue, Marilao, Valenzuela, Obando, Santa Maria, Balagtas, it also formed part of the vast Hacienda Santa Maria de Pandi, which included the towns of Santa Maria and Balagtas and parts of Angat and Bustos.

During the Philippine Revolution, Pandi played a vital and historical role in the fight for Philippine independence, Pandi is historically known for the Real de Kakarong de Sili Shrine - Inang Filipina Shrine, the site where the bloodiest revolution in Bulacan took place, where more than 3,000 Katipunero revolutionaries died.

It was in Kakarong de Sili, which about 6,000 Katipuneros from various towns of Bulacan headed by Brigadier General Eusebio Roque, a mysticist (albolaryo) better known as "Maestrong Sebio or Dimabungo"[5] - List of Filipino Generals in the Philippine Revolution of 1896 and the Filipino-American War of 1899 that the Kakarong Republic was organized shortly after the Cry of Pugad Lawin referred to as 'The Cry of Balintawak' - Andres Bonifacio a Filipino nationalist and revolutionalist who led in 'The Cry of Balintawak'.

It had streets, an independent police force, a band, a factory of falconets, bolos and repair shops for rifles and cartridges.

The 'Kakarong Republic' had a complete set of officials with Canuto Villanueva as Supreme Chief and 'Maestrong Sebio'- Eusebio Roque, who was Brigadier General.

The fort was attacked and totally destroyed on January 1, 1897, by a large Spanish force headed by General Olaguer-Feliu.

[6] Gen. Gregorio del Pilar was only a lieutenant at that time and 'The Battle of Kakarong de Sili' was his first "baptism of fire".

After the Battle of Kakarong de Sili mysticist Eusebio Roque were arrested and transferred to Bulakan town where the seat of Alcaldia Mayor located and he was sentenced to death.

The actual site of the 'Battle of Kakarong de Sili' belongs to the administrative and geographical jurisdiction of Town of Bigaa and it was given to Pandi in 1946.

Pandi is located at the center of four adjoining towns of Bulacan Province: Santa Maria; Bustos; Angat; and Balagtas.

The eastern area of Poblacion is gifted by the natural panoramic beauty of the scenery of Sierra Madre Mountains in Luzon.

Owing to this the morning climate is always cloudy and cool in some areas of the town proper of Pandi, Bulacan.

Other religious groups with strong presence in the municipality are the following: Members Church of God International or Ang Dating Daan, Iglesia ni Cristo, Jehovah's Witness, Jesus Is Lord Church, Iglesia Evangelica Metodista En Las Islas Filipinas (IEMELIF) and other Evangelical or "Born-Again" groups, as well as Pentecostals.

There is a jeepney route from Pandi to Balagtas, Bulacan where there are several commercial buses that passes by Bocaue, Bulacan exiting in baranggay 'Taal' to the Super Highway - formerly named North Diversion, North Luzon Expressway facilitating a short travel to Manila and other Metro Manila areas.

There are several commercial buses as well in central poblacion of Santa Maria, Bulacan passing through the Super Highway.

For more extensive health care programs the town folks are accommodated in the Capital City of Malolos where Bulacan Medical Center formerly Provincial Hospital located.