The Panhandle and Santa Fe Railway (P&SF) was an American rail transport company that was a subsidiary of the Atchison, Topeka and Santa Fe Railway (AT&SF), operating primarily in the Texas Panhandle.

Chartered November 2, 1886 as The Southern Kansas Railway Company of Texas, the railroad was originally created to handle the Texas portion of the line started by the Southern Kansas Railway Company, another AT&SF affiliate, from Kiowa, Kansas across what was then Indian Territory to the Texas border.

[1] The trackage of a connecting line, the Panhandle Railway Company, was acquired at a foreclosure sale in 1898, extending the line from Panhandle City to Washburn, Texas, which allowed connection by way of the Fort Worth and Denver City Railway from Washburn to Amarillo, Texas.

This included a rail line from Amarillo on to Pecos, Texas which passed through eastern New Mexico.

[1] In June 1928, the AT&SF purchased two affiliated companies: the Clinton and Oklahoma Western Railroad Company (COW), which had already completed a line from Clinton, Oklahoma to Strong City, Oklahoma[4] and was building west to the Oklahoma/Texas border, and the Clinton-Oklahoma-Western Railroad Company of Texas (COW-T), which was then completing the line from the border west through Hemphill County, Texas to terminate at Pampa in Gray County, Texas.