Panicale is a comune (municipality) in the Province of Perugia in the Italian region Umbria.

Located on the eastern slope of Mount Petrarvella, in the southeast of Valdichiana, it overlooks Lake Trasimeno and is about 35 km from Perugia.

It is one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").

[3] The municipality of Panicale contains the frazioni (subdivisions, mainly villages and hamlets) Tavernelle, Colle San Paolo, Missiano, Casalini, Colle Calzolaro, Macereto, Mongiovino, Montale, Colgiordano, Gioveto and Migliaiolo.

Panicale borders the following municipalities: Castiglione del Lago, Magione, Paciano, Perugia and Piegaro.