The panopticon cells were designed as reproductions of the Arch of Titus, Temple of Vesta, grottas and conservatories, while the wallpaper was changed frequently and displayed Arabic script.

The interior design of the Royal Panopticon of Science and Art emerged from the contemporary taste for recreational learning, which had been pioneered in London through the Great Exhibition in 1851.

[1] Visitors of the Royal Panopticon of Science and Art could view changing exhibits, including vacuum flasks, a pin making machine and a cook stove.

[1] According to The Athenaeum the Royal Panopticon of Science and Art was the most "delightful lounge in London" which exhibited music, large fountains, interesting experiments and provided opportunities for shopping.

The façade had tiles made by Mintons, shields and coats of arms of the most prominent scientists, writers and artists, including Oliver Goldsmith and Humphry Davy.