The Pantanal Matogrossense National Park (Portuguese: Parque Nacional do Pantanal Matogrossense) is a national park in the state of Mato Grosso at the border to Mato Grosso do Sul, Brazil.

The park was created by decree nº 86.392 on 24 September 1981, and is managed by the Chico Mendes Institute for Biodiversity Conservation (ICMBio).

[4] The park is in the Pantanal Biosphere Reserve, which also includes the Chapada dos Guimarães, Emas and Serra da Bodoquena national parks, and the Serra de Santa Bárbara and Nascentes do Rio Taquari, Pantanal de Rio Negro state parks.

The park's basic objective is preservation of natural ecosystems of great ecological relevance and scenic beauty and enabling scientific research, environmental education, outdoor recreation and ecological tourism.

[6] Protected species include the jaguar (Panthera onca), ocelot (Leopardus pardalis), marsh deer (Blastocerus dichotomus), giant anteater (Myrmecophaga tridactyla), giant armadillo (Priodontes maximus), giant otter (Pteronura brasiliensis), chestnut-bellied guan (Penelope ochrogaster), black-and-tawny seedeater (Sporophila nigrorufa) and the mussel Lamproscapha ensiformis.