Panther Branch is a 5.46 mi (8.79 km) long 2nd order tributary to Hyco Creek in Caswell County, North Carolina.

Panther Branch rises in Morgans Pond about 1 mile north of Prospect Hill, North Carolina, and then flows northerly to join Hyco Creek about 1.5 miles west-southwest of Frogsboro.

[2] Panther Branch drains 5.62 square miles (14.6 km2) of area, receives about 46.5 in/year of precipitation, has a topographic wetness index of 376.53, and is about 45% forested.

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