[1] It rises near Minonk, and after flowing southwestward approximately 26 miles (42 km),[2] discharges into the Mackinaw River near Eureka.

The largest town in the Panther Creek drainage is El Paso, Illinois.

Panther Creek drains much of eastern Woodford County.

[3] The creek flows through a region of intense corn and soybean cultivation, formerly part of the Illinois Grande Prairie.

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