Panther Creek is a tributary of Spring Brook in Lackawanna County, Pennsylvania, in the United States.

The surficial geology in its vicinity consists of alluvium, alluvial terrace, Wisconsinan Till, and bedrock.

At this point, it turns north-northwest for several tenths of a mile and receives Painter Creek, its only named tributary, from the left.

[1] Panther Creek joins Spring Brook 10.40 miles (16.74 km) upstream of its mouth.

[1] The surficial geology along the lower reaches of Panther Creek consists of alluvium and alluvial terrace.

[4] A total of 97 percent of the length of Panther Creek is on public land that is open to access.

[9] In the early 2000s, the Lackawanna River Watershed Conservation Plan recommended that Spring Brook Township include protection of Panther Creek in their comprehensive plans, as well as their ordinances for land use, zoning, and subdivision.

[11] Wild trout naturally reproduce in Panther Creek from its headwaters downstream to its mouth.