Panther Creek High School is a public high school located 8 miles south of Valera, Texas, United States, on FM 503; it is classified as a 1A school by the University Interscholastic League.

It is part of the Panther Creek Consolidated Independent School District located in southwestern Coleman County.

It is a 1985 consolidation of Talpa-Centennial and Mozelle.

For the 2021-2022 school year, the school was given a "B" by the Texas Education Agency.

This article about a high school in Texas is a stub.