Her parents sent her to a five-month student exchange program in the United States which eventually helped her to express herself with more confidence and to be more proficient in public speaking.

In June 2020, she was issued an arrest warrant for violating the COVID-19 safety measures and for breaching the COVID-19 pandemic emergency rule after taking part in a protest conducted by the Student Union of Thailand over the forced disappearance of prominent Thai activist Wanchalerm Satsaksit.

[11] The speech was deemed controversial and sparked a political backlash in Thailand as authorities warned that the demonstration had seriously defamed the monarchy.

[6] Following her controversial and widely reported comments, some critics and observers compared her to Agnes Chow of Hong Kong because of risking up to 15 years imprisonment under the provisions of the Thai lèse majesté law.

[10] On 20 September 2020, Panusaya along with fellow activists and protesters installed a people's plaque near Grand Palace in Bangkok.

[3][13] On 10 November 2021, the Constitutional Court ruled that Panusaya, Arnon, and Panupong aimed to overthrow the state and the monarchy in their speeches.