With a style rooted in 19th century Italian realism, she was admired for the detailed psychological analysis of her characters and her descriptions of provincial life in her native Veneto region.

[4] The couple initially lived in a palazzo on the Piazza del Santo in Padua but in 1900 moved to Mussolente where Giulio had bought the Ca' Soderini, a large villa and farming estate with one of the largest and most important parks in the Veneto region.

[5] Until the beginning of the First World War, Paola Drigo spent the winter seasons in Rome where she was active in several literary salons.

The favorable reaction of both critics and the public led to regular collaborations with two other Italian literary magazines, Nuova Antologia and L'Illustrazione Italiana.

Suffering from depression and a severe gastric ulcer which caused frequent violent hemorrhages, she was largely confined to her bed in a room overlooking the Bacchiglione River.

Her last piece, "Finistre sul fiume" ("Windows on the River"), published in the Corriere della Sera on 18 August 1937 was written from her hospital bed.