[1] Scientists have identified P. skrjabini, along with several other species including P. westermani and P. miyazakii, to be key pathogens in causing paragonimiasis in humans, primarily in Asian regions of the world.

[5] In Vietnam, since paragonimiasis was first reported there in 1906, it was presumed for 89 years that only one species of Paragonimus lung fluke, P. westermani, caused paragonmiasis in humans.

[6] However, scientists have been conducting many studies of crabs and humans infected with paragonimiasis, leading to the discovery of several previously unknown species.

[6] The few cases reported in North America of paragonimiasis are most likely the result of diseased individuals traveling to the area from a different country or people consuming infected, imported food.

[7] For P. skrjabini, it stands as a public health threat in certain areas of the world, such as the Three Gorges Reservoir where it is the primary paragonimiasis causing parasite.

[7] Changes in the environment such as pollution and the persistence of individuals' consumption habits of raw crab puts paragonimiasis epidemics at high risk.

[7] Next, in the animal or human's small intestine, the metacercarie excyst (emerge from a cyst) and travel to the abdomen before ultimately moving into the lungs.

[7] Rather, immature P. skrjabini parasites stay undeveloped and enter the human host's brain, muscles, and various other subcutaneous tissues, leading to extrapulmonary neurologic and abdominal paragonimiasis.

[5] The encysted metacercaria of P. skrjabini tend to have a round and circular shape with a cyst wall that consists of a fragile outer later and thicker middle and inner layers.

[5] In humans, P. skrjabini infections can result in a wide variety of symptoms, rendering it difficult to diagnose and challenging to quickly enact proper treatment.

[7] The ITS2 (nuclear ribosomal second internal transcribed spacer region) and CO1 (partial mitochondrial cytochrome oxidase subunit 1 gene) sequences of P. skrjabini have been registered in GenBank, which is used to determine similarities and phylogenetic relationships between various species of Paragonimus in different parts of the world.

Methods to study P. skrjabini consist of collecting samples of crabs to analyze how metacercarie is distributed in the body, purposefully infecting dogs in order to extract worms from it to later examine under a microscope, and various other tests and assays.

[7] Reasons behind this eating habit can be explained by the various culinary preferences and unique customs in the local area where Paragonimus species are endemic.

[7] Prazinquatal acts quickly to cure paragonimiasis, showing results after even one day, unlike the previously used drug bithionol, which required extended treatment and involved more severe side effects.