Although the title is a play on John Milton's epic poem Paradise Lost, the episode is a parody of the 1966 film Fantastic Voyage.
Upon returning to Earth, Fry and Bender are assigned the task of fixing the plasma fusion boiler, which promptly explodes.
Controlling the micro-droids using virtual reality gear, the crew board a miniature Planet Express ship, and enter Fry's ear.
Peter Avanzino, director of the first four broadcast seasons of Futurama and two of the straight-to-DVD movies, has stated that episodes with challenging new scenes to draw are his favorites.
"[2] The storyboard artist for this episode, Rodney Clouden, was honored with an Emmy award in 2001 for "Individual Achievement in Animation".
[6] In 2007 Entertainment Weekly named Futurama number 21 on their list of the top 25 science fiction movies and TV shows of the last 25 years (1982–2007).