The bony sclerites that strengthen the integument include tables, terminal plates and perforated plates; the sclerites in the tentacles that surround the mouth include elongated, branched, perforated and arched rods.

[3] Parastichopus regalis is found in the Mediterranean Sea, along the coasts of Africa in the eastern Atlantic Ocean, and in the tropical and subtropical western Atlantic Ocean, including the Gulf of Mexico.

[5] In a commensal arrangement, Parastichopus regalis is often host to the pearlfish Carapus acus, which enters the sea cucumber's respiratory tree via its anus.

The fish lives inside the sea cucumber during the day, emerging into the open water at night to feed.

It is edible and is eaten in parts of its range but is not a targeted species, being caught as bycatch during deepwater trawling.