Parham Road serves the northwestern suburbs of Richmond, including Tuckahoe, Laurel, and Chamberlayne.

The Parham Road name was applied to a small portion of the current route by the early 20th century.

Most of Parham Road from SR 6 to US 1 was constructed as a new four-lane divided highway by Henrico County in the late 1960s; the existing sections were upgraded at the same time.

Parham Road was completed south to its present western terminus in 1990 concurrent with the extension of SR 150 across the James River from the Southside of Richmond to Henrico County.

Parham Road briefly expands to six lanes along its SR 73 section before the state designation ends at an asymmetrical cloverleaf interchange with I-95.

Parham Road continues northeast along the northern edge of the suburb of Chamberlayne before curving south to its eastern terminus at US 301 and SR 2 (Chamberlayne Avenue) just west of the Chickahominy River, which forms the Henrico–Hanover county line, and those highways' interchange with I-295 in the adjacent county.

[3][4] Parham Road is a part of the main National Highway System from its western terminus to I-95.