[citation needed] Catholics in the faculty, student body, staff, and alumni worked tirelessly in the early 1950s to raise funds for the structure.

[4] The faculty pledged a part of their monthly salary, while the students contributed from their own allowances to fund the construction of the church.

[citation needed] In December 1955, the inner structure of the church which includes the pews, crucifix, tabernacle, altar, marble floor design, and skylight were worked on, as well as the outside landscaping, pathways, and fences.

Its interior was an obra maestra of yet another conglomeration of now National Artists: Vicente Manansala and Ang Kiukok, Arturo Luz, and Napoleon Abueva.

Structural, electric and water systems were also planned by Felisberto G. Reyes, Lamberto UN Ocampo, and Jose M. Segovia with Agapito S. Pineda.

The Church of Holy Sacrifice became the first circular chapel with the altar in its center in the country, and the first to have a thin shell concrete dome.

The ceiling of the concrete dome church was left bare and a dramatic use of colored lights mark the changing seasons of worship.

This ring beam, in turn, supports the three-inch thick concrete shell of the dome that spans 29.26 metres (96.0 ft).

The fifteen murals depicting the Stations of the Cross that adorn the circular walls are by Vicente Manansala assisted by Ang Kiukok.

During the recognition ceremony, National Historical Institute Chairman Ambeth R. Ocampo lauded the church as a "masterpiece of Filipino artistry and ingenuity".

[This quote needs a citation] Repairs of the church were planned on early 2020, but was postponed to begin on July 2020 due to the pandemic.

[7] The rehabilitation project started through a series of consultations with UP officials in an effort to bring back the 65-year-old building’s original state.

Developer DMCI Homes facilitated the following repairs in the chapel: repair of masonry cracks; de-clogging of downspouts and drains; installation of new electrical fixtures; and, exterior repainting on the chapel’s iconic dome and roof, as well as of its walls, columns, eaves, under slabs, ceilings, and railings.