Parkers Crossroads is a city in Henderson County, Tennessee, United States.

Interstate 40 crosses Tennessee State Route 22 at Exit 108 just south of the original crossroads.

According to the United States Census Bureau, Parkers Crossroads has a total area of 3.7 square miles (9.6 km2), all land.

24.3% of all households were made up of individuals, and 8.4% had someone living alone who was 65 years of age or older.

About 19.0% of families and 18.7% of the population were below the poverty line, including 12.5% of those under the age of eighteen and 21.6% of those 65 or over.