The George Parks Highway (numbered Interstate A-4 and signed Alaska Route 3), usually called simply the Parks Highway, runs 323 miles (520 km) from the Glenn Highway 35 miles (56 km) north of Anchorage to Fairbanks in the Alaska Interior.

It is the main route between Anchorage and Fairbanks (Alaska's two largest metropolitan areas), the principal access to Denali National Park and Preserve and Denali State Park, and the main highway in the Matanuska-Susitna Valley.

The 0 (zero) mile marker for the Glenn Highway is at its terminus in downtown Anchorage at the intersection of East 5th Avenue and Gambell Street.

There are two sections of the highway that are built to freeway standards.

[2][3] In the "Mile" column, the first number is the actual mileage of the Parks Highway, and the second mile is based on the mileposts along the highway itself.