In 1960 Parkville became home to the Victorian College of Pharmacy, on Royal Parade, which is now a campus of Monash University.

The Athlete's Village for the 2006 Commonwealth Games was built on the grounds of the former Royal Park Psychiatric Hospital located in Parkville.

[3] The residential part of Parkville South, commenced in 1861, is a Conservation Area under the Register of the National Estate and contains almost all of the suburb's housing.

Seven bus routes service Parkville: The main arterial road is Elizabeth Street, which becomes Royal Parade before becoming Sydney Road and the Hume Highway, the main highway heading towards Sydney.

Royal Park is the main railway station in Parkville, located in Royal Park to the north and adjacent to the Melbourne Zoo, and is on the Upfield line, serviced by Metro Trains Melbourne.

The planned Melbourne Metro Rail Project tunnel will have an underground Parkville railway station.

Royal Park is home to the Parkville District Cricket Club, who are based at Brens Pavilion.